BMI1

BMI1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2H0D, 3RPG, 4R8P
Identifiers
Aliases	BMI1, FLVI2/PCGF4, RNF51, flvi-2/bmi-1, BMI1 proto-oncogene, polycomb ring finger
External IDs	OMIM: 164831; HomoloGene: 136787; GeneCards: BMI1; OMA:BMI1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	22,331,484 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; Epithelium of choroid plexus; ; endothelial cell; ; optic nerve; ; Brodmann area 23; ; visceral pleura; ; corpus callosum; ; retinal pigment epithelium; ; tibia; ; parietal pleura;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	promoter-specific chromatin binding; RING-like zinc finger domain binding; metal ion binding; protein binding; zinc ion binding;
Cellular component	cytoplasm; ubiquitin ligase complex; nucleoplasm; PRC1 complex; PcG protein complex; nucleus; cytosol; nuclear body;
Biological process	regulation of transcription, DNA-templated; positive regulation of fibroblast proliferation; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; segment specification; negative regulation of gene expression, epigenetic; positive regulation of ubiquitin-protein transferase activity; regulation of gene expression; histone H2A-K119 monoubiquitination; negative regulation of G0 to G1 transition; chromatin organization; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	648
	n/a
	ENSG00000168283
	n/a
	P35226; Q5T8Z6
	n/a
	NM_005180
	n/a
	NP_001190991; NP_005171
	n/a
	Wikidata
View/Edit Human

Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-specific Moloney murine leukemia virus integration site 1). BMI1 is a polycomb ring finger oncogene.