Bone morphogenetic protein 8B

BMP8B
Identifiers
Aliases	BMP8B, BMP8, OP2, bone morphogenetic protein 8b
External IDs	OMIM: 602284; MGI: 104515; HomoloGene: 74865; GeneCards: BMP8B; OMA:BMP8B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	39,788,865 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	123,237,045 bp
RNA expression pattern
	Top expressed in
	tibia; ; spinal ganglia; ; trigeminal ganglion; ; jejunal mucosa; ; tibial nerve; ; retinal pigment epithelium; ; sural nerve; ; trabecular bone; ; duodenum; ; mucosa of colon;
	Top expressed in
	decidua; ; gastrula; ; intestinal villus; ; calvaria; ; hair follicle; ; molar; ; jejunum; ; embryo; ; Ileal epithelium; ; body of femur;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transforming growth factor beta receptor binding; cytokine activity; BMP receptor binding; growth factor activity;
Cellular component	extracellular region; extracellular space;
Biological process	regulation of apoptotic process; multicellular organism development; skeletal system development; positive regulation of pathway-restricted SMAD protein phosphorylation; cartilage development; cell differentiation; regulation of MAPK cascade; SMAD protein signal transduction; cell development; BMP signaling pathway; ossification; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	656
	12163
	ENSG00000116985
	ENSMUSG00000032726
	P34820
	P34821
	NM_001720
	NM_001256019; NM_007558
	NP_001711
	NP_001242948; NP_031584
	Wikidata
View/Edit Human	View/Edit Mouse

Bone morphogenetic protein 8B is a protein that in humans is encoded by the BMP8B gene.

The protein encoded by this gene is a member of the TGF-β superfamily. It has close sequence homology to BMP7 and BMP5 and is believed to play a role in bone and cartilage development. It has been shown to be expressed in the hippocampus of murine embryos.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.