BOK (gene)

BOK
Identifiers
Aliases	BOK, BCL2L9, BOKL, BCL2-related ovarian killer, BCL2 family apoptosis regulator, BCL2 family apoptosis regulator BOK
External IDs	OMIM: 605404; MGI: 1858494; HomoloGene: 9632; GeneCards: BOK; OMA:BOK - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	241,574,131 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,623,486 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; inferior ganglion of vagus nerve; ; right lobe of liver; ; skin of arm; ; substantia nigra; ; Medulla Oblongata; ; Hypothalamus; ; subthalamic nucleus; ; adipose tissue; ; subcutaneous adipose tissue;
	Top expressed in
	decidua; ; lip; ; gastrula; ; Rostral migratory stream; ; dentate gyrus of hippocampal formation granule cell; ; right kidney; ; CA3 field; ; pyloric antrum; ; medial dorsal nucleus; ; cumulus cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; protein binding; signaling receptor binding; ubiquitin protein ligase binding; protein homodimerization activity; protein heterodimerization activity; BH domain binding;
Cellular component	integral component of membrane; mitochondrion; nucleus; nuclear outer membrane; cytoplasm; mitochondrial inner membrane; endosome; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; membrane; early endosome membrane; mitochondrial membranes; trans-Golgi network membrane; cis-Golgi network membrane; recycling endosome membrane; mitochondrial outer membrane;
Biological process	regulation of apoptotic process; neuron apoptotic process; male gonad development; positive regulation of execution phase of apoptosis; oligodendrocyte differentiation; brain development; intrinsic apoptotic signaling pathway by p53 class mediator; cell population proliferation; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; release of cytochrome c from mitochondria; cellular component disassembly involved in execution phase of apoptosis; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; regulation of autophagy; positive regulation of apoptotic process; negative regulation of neuron apoptotic process; protein complex oligomerization; regulation of cytosolic calcium ion concentration; negative regulation of mitochondrial depolarization; negative regulation of necroptotic process; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; regulation of chorionic trophoblast cell proliferation; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of PERK-mediated unfolded protein response; regulation of granulosa cell apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; extrinsic apoptotic signaling pathway in absence of ligand;
	Sources:Amigo / QuickGO
Orthologs
	666
	51800
	ENSG00000176720
	ENSMUSG00000026278
	Q9UMX3
	O35425
	NM_032515
	NM_016778
	NP_115904
	NP_058058
	Wikidata
View/Edit Human	View/Edit Mouse

Bok (Bcl-2 related ovarian killer) is a protein-coding gene of the Bcl-2 family that is found in many invertebrates and vertebrates. It induces apoptosis, a special type of cell death. Currently, the precise function of Bok in this process is unknown.