BOP1

BOP1
Identifiers
Aliases	BOP1, block of proliferation 1, BOP1 ribosomal biogenesis factor
External IDs	OMIM: 610596; MGI: 1334460; HomoloGene: 6612; GeneCards: BOP1; OMA:BOP1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,291,438 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,361,477 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; right hemisphere of cerebellum; ; left lobe of thyroid gland; ; pituitary gland; ; anterior pituitary; ; right uterine tube; ; gastrocnemius muscle; ; right frontal lobe; ; mucosa of transverse colon; ; apex of heart;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; epiblast; ; somite; ; embryo; ; embryo; ; yolk sac; ; primitive streak; ; mandibular prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ribonucleoprotein complex binding; protein binding; RNA binding;
Cellular component	nucleolus; nucleus; PeBoW complex; nucleoplasm; preribosome, large subunit precursor; ribonucleoprotein complex;
Biological process	ribosomal large subunit biogenesis; cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); cell population proliferation; ribosome biogenesis; regulation of cell cycle; rRNA processing; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ribosomal large subunit assembly; regulation of signal transduction by p53 class mediator; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);
	Sources:Amigo / QuickGO
Orthologs
	23246
	12181
	ENSG00000261236; ENSG00000285301
	ENSMUSG00000022557
	Q14137
	P97452
	NM_015201
	NM_013481
	NP_056016
	NP_038509
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene. It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle. It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA.