BRCC3

BRCC3
Identifiers
Aliases	BRCC3, BRCC36, C6.1A, CXorf53, BRCA1/BRCA2-containing complex subunit 3
External IDs	OMIM: 300617; MGI: 2389572; HomoloGene: 11530; GeneCards: BRCC3; OMA:BRCC3 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	155,123,077 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	74,497,607 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; oral cavity; ; buccal mucosa cell; ; mucosa of sigmoid colon; ; corpus epididymis; ; biceps brachii; ; rectum; ; Skeletal muscle tissue of biceps brachii; ; bronchial epithelial cell; ; islet of Langerhans;
	Top expressed in
	tail of embryo; ; genital tubercle; ; otic placode; ; primitive streak; ; gastrula; ; facial motor nucleus; ; medial vestibular nucleus; ; otic vesicle; ; submandibular gland; ; seminal vesicula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	enzyme regulator activity; metal ion binding; polyubiquitin modification-dependent protein binding; peptidase activity; protein binding; hydrolase activity; metallopeptidase activity; thiol-dependent deubiquitinase; Lys63-specific deubiquitinase activity;
Cellular component	cytoplasm; spindle pole; nuclear ubiquitin ligase complex; ubiquitin ligase complex; nucleoplasm; cytoskeleton; nucleus; cytosol; BRCA1-A complex; BRISC complex;
Biological process	response to ionizing radiation; positive regulation of DNA repair; proteolysis; cellular response to DNA damage stimulus; cell division; cell cycle; histone H2A K63-linked deubiquitination; double-strand break repair via nonhomologous end joining; response to X-ray; regulation of catalytic activity; double-strand break repair; DNA repair; protein deubiquitination; protein K63-linked deubiquitination; mitotic G2 DNA damage checkpoint signaling; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	79184
	210766
	ENSG00000185515
	ENSMUSG00000031201
	P46736
	P46737
	NM_001018055; NM_001242640; NM_024332
	NM_001166457; NM_001166459; NM_145956; NM_001358736; NM_001358737
	NP_001018065; NP_001229569; NP_077308
	NP_001159929; NP_001159931; NP_666068; NP_001345665; NP_001345666
	Wikidata
View/Edit Human	View/Edit Mouse

Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.