BRD8

BRD8
Identifiers
Aliases	BRD8, SMAP, SMAP2, p120, bromodomain containing 8
External IDs	OMIM: 602848; MGI: 1925906; HomoloGene: 41790; GeneCards: BRD8; OMA:BRD8 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	138,178,953 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	34,757,654 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; ventricular zone; ; pituitary gland; ; anterior pituitary; ; right lobe of thyroid gland; ; right uterine tube; ; left lobe of thyroid gland; ; middle temporal gyrus; ; buccal mucosa cell;
	Top expressed in
	neural layer of retina; ; Rostral migratory stream; ; ventricular zone; ; tail of embryo; ; genital tubercle; ; spermatocyte; ; blastocyst; ; ganglionic eminence; ; primitive streak; ; yolk sac;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; protein binding; nuclear receptor activity;
Cellular component	mitochondrion; nucleus; nucleoplasm; Swr1 complex; NuA4 histone acetyltransferase complex;
Biological process	regulation of transcription by RNA polymerase II; histone H2A acetylation; regulation of growth; cell surface receptor signaling pathway; regulation of transcription, DNA-templated; transcription, DNA-templated; signal transduction; histone H4 acetylation; positive regulation of transcription by RNA polymerase II; intracellular receptor signaling pathway; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	10902
	78656
	ENSG00000112983
	ENSMUSG00000003778
	Q9H0E9
	Q8R3B7
NM_001164326; NM_001300961; NM_001300962; NM_001300966; NM_006696;
	NM_139199; NM_183359
	NM_001289606; NM_001289607; NM_030147; NM_001361136
NP_001157798; NP_001287890; NP_001287891; NP_001287895; NP_006687;
	NP_631938
	NP_001276535; NP_001276536; NP_084423; NP_001348065
	Wikidata
View/Edit Human	View/Edit Mouse

Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.