BRMS1

BRMS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XUS, 4AUV
Identifiers
Aliases	BRMS1, breast cancer metastasis suppressor 1, transcriptional repressor and anoikis regulator, BRMS1 transcriptional repressor and anoikis regulator
External IDs	OMIM: 606259; MGI: 2388804; HomoloGene: 32260; GeneCards: BRMS1; OMA:BRMS1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,345,125 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,099,945 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; mucosa of transverse colon; ; monocyte; ; skin of leg; ; skin of abdomen; ; body of stomach; ; body of pancreas; ; sural nerve; ; minor salivary glands; ; mucosa of esophagus;
	Top expressed in
	spermatid; ; blastocyst; ; yolk sac; ; morula; ; lip; ; right kidney; ; granulocyte; ; embryo; ; embryo; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone deacetylase binding; protein binding; NF-kappaB binding; histone deacetylase activity;
Cellular component	cytoplasm; Sin3-type complex; nucleus; nucleoplasm;
Biological process	positive regulation of protein deacetylation; positive regulation of anoikis; negative regulation of transcription, DNA-templated; negative regulation of NF-kappaB transcription factor activity; negative regulation of transcription by RNA polymerase II; histone deacetylation; regulation of transcription, DNA-templated; transcription, DNA-templated; apoptotic process; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	25855
	107392
	ENSG00000174744
	ENSMUSG00000080268
	Q9HCU9
	Q99N20
	NM_015399; NM_001024957; NM_001024958
	NM_134155; NM_001374047; NM_001374048
	NP_001020128; NP_056214
	NP_598916; NP_001360976; NP_001360977
	Wikidata
View/Edit Human	View/Edit Mouse

Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.