BTBD9

BTBD9
Identifiers
Aliases	BTBD9, dJ322I12.1, BTB domain containing 9
External IDs	OMIM: 611237; MGI: 1916625; HomoloGene: 14995; GeneCards: BTBD9; OMA:BTBD9 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	38,640,148 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	30,795,462 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; mucosa of paranasal sinus; ; bone marrow cells; ; sural nerve; ; tibialis anterior muscle; ; Achilles tendon; ; middle temporal gyrus; ; lower lobe of lung; ; prefrontal cortex; ; epithelium of nasopharynx;
	Top expressed in
	interventricular septum; ; dentate gyrus of hippocampal formation granule cell; ; otolith organ; ; utricle; ; spermatid; ; neural layer of retina; ; neural tube; ; hippocampus proper; ; visual cortex; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin protein ligase binding;
Cellular component	cytoplasm; SCF ubiquitin ligase complex;
Biological process	long-term memory; serotonin metabolic process; circadian sleep/wake cycle, non-REM sleep; sensory perception of temperature stimulus; multicellular organismal iron ion homeostasis; regulation of synaptic vesicle endocytosis; proteasome-mediated ubiquitin-dependent protein catabolic process; circadian behavior; modulation of chemical synaptic transmission; regulation of proteolysis; adult locomotory behavior;
	Sources:Amigo / QuickGO
Orthologs
	114781
	224671
	ENSG00000183826
	ENSMUSG00000062202
	Q96Q07
	Q8C726
	NM_001099272; NM_001172418; NM_052893; NM_152733
	NM_027060; NM_172618
	NP_001092742; NP_001165889; NP_443125; NP_689946
	NP_081336; NP_766206
	Wikidata
View/Edit Human	View/Edit Mouse

BTB domain containing 9 is a protein that in humans is encoded by the BTBD9 gene.

BTBD9 is in a subgroup of BTB(POZ) proteins, which contribute to the forming of limbs and determination of cell fate in developing Drosophila melanogaster. BTB(POZ) proteins also play a role in cellular functions such as: cytoskeleton regulation, transcription regulation, the gating and assembly of ion channels, and ubiquitination of proteins. BTBD9 is highly expressed throughout the brain and shows variable levels of expression in most other body tissues.

The gene is located on the short arm of chromosome 6 and the domain contains eight exons and seven introns. The chromosome 6 locational domain that codes for BTB(POZ) proteins is understood to contain genes encoding protein-protein interactions. BTBD9 is a protein located in cellular cytosol and also expressed within Human embryonic kidney cell lineages. There is also evidence suggesting that BTBD9 is highly expressed within the human nervous system from comparison analysis to Drosophila and human cell studies.