BUB3

BUB3
Identifiers
Aliases	BUB3, BUB3L, hmitotic checkpoint protein, BUB3 mitotic checkpoint protein
External IDs	OMIM: 603719; MGI: 1343463; HomoloGene: 3470; GeneCards: BUB3; OMA:BUB3 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	123,170,467 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	131,173,624 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; sperm; ; epithelium of nasopharynx; ; germinal epithelium; ; Epithelium of choroid plexus; ; ventricular zone; ; lymph node; ; embryo; ; ganglionic eminence; ; gonad;
	Top expressed in
	vestibular sensory epithelium; ; primitive streak; ; maxillary prominence; ; mandibular prominence; ; abdominal wall; ; stria vascularis; ; medial ganglionic eminence; ; endocardial cushion; ; condyle; ; somite;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin binding;
Cellular component	cytosol; chromosome; nucleoplasm; chromosome, centromeric region; nucleus; kinetochore; mitotic checkpoint complex; bub1-bub3 complex;
Biological process	chromosome segregation; cell division; regulation of chromosome segregation; meiosis; mitotic sister chromatid segregation; cell cycle; anaphase-promoting complex-dependent catabolic process; attachment of spindle microtubules to kinetochore; mitotic spindle assembly checkpoint signaling; protein localization to kinetochore; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9184
	12237
	ENSG00000154473
	ENSMUSG00000066979
	O43684
	Q9WVA3
	NM_004725; NM_001007793
	NM_009774; NM_001317350
	NP_001007794; NP_004716
	NP_001304279; NP_033904
	Wikidata
View/Edit Human	View/Edit Mouse

Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene.

Bub3 is a protein involved with the regulation of the Spindle Assembly Checkpoint (SAC); though BUB3 is non-essential in yeast, it is essential in higher eukaryotes. As one of the checkpoint proteins, Bub3 delays the irreversible onset of anaphase through direction of kinetochore localization during prometaphase to achieve biorientation. In directing the kinetochore-microtubule interaction, this ensures the proper (and consequently, bioriented) attachment of the chromosomes prior to anaphase. Bub3 and its related proteins that form the Spindle Assembly Checkpoint (SAC) inhibit the action of the Anaphase Promoting Complex (APC), preventing early anaphase entry and mitotic exit; this serves as a mechanism for the fidelity of chromosomal segregation.