Bentazepam

Bentazepam
Clinical data
Trade names	Tiadipona (ES)
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral (tablets)
ATC code	N05BA24 (WHO) ;
Legal status
Legal status	US: Unscheduled;
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	2–4 hours
Excretion	Renal
Identifiers
	IUPAC name 5-phenyl-3,4,6,7,8,9-hexahydro-[1]benzothiolo[2,3-e][1,4]diazepin-2-one;
CAS Number	29462-18-8 ;
PubChem CID	34592;
ChemSpider	11248641 ;
UNII	66JKK43S1Z;
KEGG	D03083 ;
ChEMBL	ChEMBL1521495 ;
CompTox Dashboard (EPA)	DTXSID40897431 ;
ECHA InfoCard	100.123.659
Chemical and physical data
Formula	C17H16N2OS
Molar mass	296.39 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1CN=C(C2=CC=CC=C2)C3=C(N1)SC4=C3CCCC4;
	InChI InChI=1S/C17H16N2OS/c20-14-10-18-16(11-6-2-1-3-7-11)15-12-8-4-5-9-13(12)21-17(15)19-14/h1-3,6-7H,4-5,8-10H2,(H,19,20) ; Key:AIZFEOPQVZBNGH-UHFFFAOYSA-N ;
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Bentazepam (also known as Thiadipone, Tiadipona) is a thienodiazepine which is a benzodiazepine analog.

It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Peak plasma rates are achieved in around 2,5 hours after oral administration. The elimination half-life is between approximately 2–4 hours. Bentazepam is effective as an anxiolytic.

A severe benzodiazepine overdose with bentazepam may result in coma and respiratory failure. Adverse effects include dry mouth, somnolence, asthenia, dyspepsia, constipation, nausea and drug-induced lymphocytic colitis has been associated with bentazepam. Severe liver damage and hepatitis has also been associated with bentazepam. Whilst liver failure from bentazepam is considered to be rare, liver function monitoring has been recommended for all patients taking bentazepam.