Inotuzumab ozogamicin
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | CD22 |
| Clinical data | |
| Trade names | Besponsa |
| Other names | CMC-544 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a617041 |
| License data | |
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| Routes of administration | Intravenous |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | 97% (cytotoxic agent) |
| Elimination half-life | 12.3 days |
| Identifiers | |
| CAS Number | |
| DrugBank | |
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| UNII | |
| KEGG | |
| Chemical and physical data | |
| Formula | C6518H10002N1738O2036S42 |
| Molar mass | 146634.36 g·mol−1 |
| (what is this?) (verify) | |
Inotuzumab ozogamicin, sold under the brand name Besponsa, is an antibody-drug conjugate medication used to treat relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). It is administered by intravenous infusion.
Inotuzumab ozogamicin consists of a humanized monoclonal antibody against CD22 (inotuzumab), linked to a cytotoxic agent from the class of calicheamicins called ozogamicin.
The US Food and Drug Administration considers it to be a first-in-class medication.