Β-Thromboglobulin
| β-Thromboglobulin | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CXCL7 | ||||||
| Alt. symbols | CTAP3, CXCL7, SCYB7, TGB1, THBGB1 | ||||||
| NCBI gene | 5473 | ||||||
| HGNC | 9240 | ||||||
| OMIM | 121010 | ||||||
| RefSeq | NP_002695 | ||||||
| UniProt | P02775 | ||||||
| Other data | |||||||
| Locus | Chr. 4 q13.3 | ||||||
| |||||||
β-Thromboglobulin (β-TG), or beta-thromboglobulin, is a chemokine protein secreted by platelets. It is a type of chemokine (C-X-C motif) ligand 7. Along with platelet factor 4 (PF4), β-TG is one of the best-characterized platelet-specific proteins. β-TG and PF4 are stored in platelet alpha granules and are released during platelet activation. As a result, they are useful markers of platelet activation. β-TG also has multiple biological activities, for instance being involved in maturation of megakaryocytes.