Β-Glucuronidase
| β-Glucuronidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Glucuronidase Homotetramer (assumed biological unit) | |||||||||
| Identifiers | |||||||||
| EC no. | 3.2.1.31 | ||||||||
| CAS no. | 9001-45-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| β-Glucuronidase | |||||||
|---|---|---|---|---|---|---|---|
β-Glucuronidase asymmetric unit showing active site residues Glu451, Tyr504, and Glu540, along with the potentially supporting Asn450 residue | |||||||
| Identifiers | |||||||
| Symbol | GUSB | ||||||
| NCBI gene | 2990 | ||||||
| HGNC | 4696 | ||||||
| OMIM | 611499 | ||||||
| RefSeq | NM_000181 | ||||||
| UniProt | P08236 | ||||||
| Other data | |||||||
| EC number | 3.2.1.31 | ||||||
| Locus | Chr. 7 q11.21 | ||||||
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β-Glucuronidases are members of the glycosidase family of enzymes that catalyze breakdown of complex carbohydrates. Human β-glucuronidase is a type of glucuronidase (a member of glycosidase Family 2) that catalyzes hydrolysis of β-D-glucuronic acid residues from the non-reducing end of mucopolysaccharides (also referred to as glycosaminoglycans) such as heparan sulfate. Human β-glucuronidase is located in the lysosome. In the gut, brush border β-glucuronidase converts conjugated bilirubin to the unconjugated form for reabsorption. β-Glucuronidase is also present in breast milk, which contributes to neonatal jaundice. The protein is encoded by the GUSB gene in humans and by the uidA gene in bacteria.