Big dynorphin

Big dynorphin is an endogenous opioid peptide of the dynorphin family that is composed of both dynorphin A and dynorphin B. It is derived from the precursor protein prodynorphin, encoded by the PDYN gene. Big dynorphin is notable for its potent activity at opioid receptors and its role in modulating pain, stress, emotion, and neurophysiological functions such as learning and memory. Big dynorphin has the amino acid sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-Lys-Arg-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr. It has nociceptive and anxiolytic-like properties, as well as effects on memory in mice.

Big dynorphin is a principal endogenous, agonist at the human kappa-opioid receptor.

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