Biglycan

BGN
Identifiers
Aliases	BGN, DSPG1, PG-S1, PGI, SLRR1A, biglycan, SEMDX, MRLS
External IDs	OMIM: 301870; MGI: 88158; HomoloGene: 1293; GeneCards: BGN; OMA:BGN - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	153,509,546 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	72,539,539 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; right coronary artery; ; tendon of biceps brachii; ; popliteal artery; ; tibial arteries; ; left coronary artery; ; tibia; ; right lung; ; gallbladder;
	Top expressed in
	calvaria; ; tunica media of zone of aorta; ; stroma of bone marrow; ; ascending aorta; ; ankle joint; ; umbilical cord; ; body of femur; ; aortic valve; ; ankle; ; molar;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase inhibitor activity; glycosaminoglycan binding; extracellular matrix structural constituent; extracellular matrix binding; extracellular matrix structural constituent conferring compression resistance; protein binding;
Cellular component	cytoplasm; extracellular matrix; intracellular anatomical structure; transport vesicle; cell surface; lysosomal lumen; Golgi lumen; sarcolemma; extracellular exosome; extracellular space; extracellular region; collagen-containing extracellular matrix;
Biological process	glycosaminoglycan metabolic process; negative regulation of protein kinase activity; cytokine-mediated signaling pathway; chondroitin sulfate biosynthetic process; extracellular matrix organization; blood vessel remodeling; chondroitin sulfate catabolic process; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; dermatan sulfate biosynthetic process; negative regulation of receptor signaling pathway via JAK-STAT; biological process;
	Sources:Amigo / QuickGO
Orthologs
	633
	12111
	ENSG00000182492
	ENSMUSG00000031375
	P21810
	P28653
	NM_001711
	NM_007542
	NP_001702
	NP_031568
	Wikidata
View/Edit Human	View/Edit Mouse

Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans, biglycan is encoded by the BGN gene which is located on the X chromosome.

The name "biglycan" was proposed in an article by Fisher, Termine and Young in an article in the Journal of Biological Chemistry in 1989 because the proteoglycan contained two GAG chains; formerly it was known as proteoglycan-I (PG-I).