Blue rubber bleb nevus syndrome

Blue rubber bleb nevus syndrome
Other namesBRBNS, or Blue rubber bleb syndrome, or Blue rubber-bleb nevus or Bean syndrome
The cutaneous vascular malformations of blue rubber bleb nevus syndrome
SpecialtyOncology 

Blue rubber bleb nevus syndrome is a rare disorder that consists mainly of abnormal blood vessels affecting the skin or internal organs – usually the gastrointestinal tract. The disease is characterized by the presence of fluid-filled blisters (blebs) as visible, circumscribed, chronic lesions (nevi).

BRBNS is caused by somatic mutations in the TEK (TIE2) gene. It was described by William Bennett Bean in 1958.

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