Bone morphogenetic protein 2

BMP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ES7, 1REU, 1REW, 2GOO, 2H62, 2H64, 2QJ9, 2QJA, 2QJB, 3BK3, 3BMP, 4MID, 4N1D, 4UHY, 4UHZ, 4UI0, 4UI1, 4UI2
Identifiers
Aliases	BMP2, BDA2, BMP2A, bone morphogenetic protein 2, SSFSC, SSFSC1
External IDs	OMIM: 112261; MGI: 88177; HomoloGene: 926; GeneCards: BMP2; OMA:BMP2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	6,780,246 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	133,404,805 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; pancreatic ductal cell; ; retinal pigment epithelium; ; mucosa of sigmoid colon; ; lower lobe of lung; ; pylorus; ; periodontal fiber; ; mucosa of urinary bladder; ; stromal cell of endometrium; ; glomerulus;
	Top expressed in
	gastrula; ; transitional epithelium of urinary bladder; ; epithelium of stomach; ; left colon; ; ciliary body; ; mucous cell of stomach; ; Apical ectodermal ridge; ; sebaceous gland; ; retinal pigment epithelium; ; pyloric antrum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; cytokine activity; co-receptor binding; phosphatase activator activity; growth factor activity; BMP receptor binding; protein binding; NAD-retinol dehydrogenase activity; SMAD binding; protein heterodimerization activity; transforming growth factor beta receptor binding;
Cellular component	extracellular region; cell surface; BMP receptor complex; extracellular space; intracellular membrane-bounded organelle;
Biological process	skeletal system development; positive regulation of Wnt signaling pathway by BMP signaling pathway; positive regulation of protein phosphorylation; mesenchyme development; negative regulation of cell cycle; odontogenesis of dentin-containing tooth; telencephalon regionalization; protein phosphorylation; atrioventricular valve morphogenesis; proteoglycan metabolic process; mesenchymal cell differentiation; pericardium development; positive regulation of ERK1 and ERK2 cascade; BMP signaling pathway involved in heart induction; animal organ morphogenesis; inner ear development; cardiocyte differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of cell population proliferation; positive regulation of p38MAPK cascade; pathway-restricted SMAD protein phosphorylation; cell fate commitment; regulation of transcription, DNA-templated; SMAD protein signal transduction; ossification; in utero embryonic development; mesenchymal cell proliferation involved in ureteric bud development; regulation of odontogenesis of dentin-containing tooth; positive regulation of transcription, DNA-templated; positive regulation of Wnt signaling pathway; heart development; telencephalon development; branching involved in ureteric bud morphogenesis; negative regulation of Wnt signaling pathway involved in heart development; cartilage development; bone mineralization involved in bone maturation; positive regulation of cartilage development; positive regulation of neuron differentiation; positive regulation of cell differentiation; thyroid-stimulating hormone-secreting cell differentiation; inflammatory response; positive regulation of fat cell differentiation; negative regulation of steroid biosynthetic process; positive regulation of MAPK cascade; Notch signaling pathway; bone mineralization; cell differentiation; chondrocyte differentiation; corticotropin hormone secreting cell differentiation; positive regulation of astrocyte differentiation; positive regulation of bone mineralization; cellular response to organic cyclic compound; positive regulation of ossification; negative regulation of transcription by RNA polymerase II; positive regulation of epithelial to mesenchymal transition; positive regulation of phosphatase activity; negative regulation of calcium-independent cell-cell adhesion; positive regulation of osteoblast differentiation; protein destabilization; embryonic heart tube anterior/posterior pattern specification; osteoblast differentiation; epithelial to mesenchymal transition; positive regulation of protein binding; negative regulation of transcription, DNA-templated; positive regulation of odontogenesis; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; negative regulation of aldosterone biosynthetic process; positive regulation of osteoblast proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; positive regulation of cell migration; negative regulation of cortisol biosynthetic process; cell-cell signaling; positive regulation of pathway-restricted SMAD protein phosphorylation; cellular response to growth factor stimulus; cellular response to BMP stimulus; cardiac muscle tissue morphogenesis; endocardial cushion morphogenesis; multicellular organism development; negative regulation of cardiac muscle cell differentiation; positive regulation of apoptotic process; negative regulation of insulin-like growth factor receptor signaling pathway; positive regulation of transcription by RNA polymerase II; cardiac epithelial to mesenchymal transition; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of gene expression; BMP signaling pathway; cardiac muscle cell differentiation; cell development; regulation of signaling receptor activity; negative regulation of gene expression; response to bacterium; regulation of apoptotic process; regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	650
	12156
	ENSG00000125845
	ENSMUSG00000027358
	P12643
	P21274
	NM_001200
	NM_007553
	NP_001191
	NP_031579
	Wikidata
View/Edit Human	View/Edit Mouse

Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins.