Bone morphogenetic protein 3

BMP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QCQ
Identifiers
Aliases	BMP3, BMP-3A, bone morphogenetic protein 3
External IDs	OMIM: 112263; MGI: 88179; HomoloGene: 927; GeneCards: BMP3; OMA:BMP3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	81,057,627 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	99,032,255 bp
RNA expression pattern
	Top expressed in
	muscle layer of sigmoid colon; ; testicle; ; rectum; ; transverse colon; ; mucosa of transverse colon; ; tibial nerve; ; olfactory zone of nasal mucosa; ; palpebral conjunctiva; ; gallbladder; ; epithelium of colon;
	Top expressed in
	perichondrium; ; lower lip; ; upper lip; ; urinary bladder; ; nucleus pulposus; ; cervical ganglion; ; urethra; ; skeleton; ; facial skeleton; ; ureter;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; BMP receptor binding; transforming growth factor beta receptor binding; growth factor activity; signaling receptor binding;
Cellular component	extracellular region; extracellular exosome; extracellular space;
Biological process	regulation of apoptotic process; skeletal system development; cell differentiation; regulation of MAPK cascade; SMAD protein signal transduction; cell development; ossification; cell-cell signaling; positive regulation of pathway-restricted SMAD protein phosphorylation; BMP signaling pathway; multicellular organism development; cartilage development; osteoblast differentiation; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	651
	110075
	ENSG00000152785
	ENSMUSG00000029335
	P12645
	Q8BHE5
	NM_001201
	NM_173404; NM_001310677
	NP_001192
	NP_001297606; NP_775580
	Wikidata
View/Edit Human	View/Edit Mouse

Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene.

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, unlike other bone morphogenetic proteins (BMP's) inhibits the ability of other BMP's to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured tissues.