Bosentan

Bosentan
Clinical data
Trade names	Tracleer, Stayveer, Safebo
AHFS/Drugs.com	Monograph
MedlinePlus	a605001
License data	US DailyMed: Bosentan;
Pregnancy; category	AU: X (High risk);
Routes of; administration	By mouth
ATC code	C02KX01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only; EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	50%
Protein binding	>98%
Metabolism	Liver
Elimination half-life	5 hours
Identifiers
	IUPAC name 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide;
CAS Number	147536-97-8 ;
PubChem CID	104865;
IUPHAR/BPS	3494;
DrugBank	DB00559 ;
ChemSpider	94651 ;
UNII	XUL93R30K2;
KEGG	D07538 ; as monohydrate: D01227 ;
ChEBI	CHEBI:51450 ;
ChEMBL	ChEMBL957 ;
CompTox Dashboard (EPA)	DTXSID7046627 ;
ECHA InfoCard	100.171.206
Chemical and physical data
Formula	C27H29N5O6S
Molar mass	551.62 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2c(c(nc(n2)c3ncccn3)OCCO)Oc4ccccc4OC;
	InChI InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32) ; Key:GJPICJJJRGTNOD-UHFFFAOYSA-N ;
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Bosentan, sold under the brand name Tracleer among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary artery hypertension (PAH).

Bosentan is available as film-coated tablets (62.5 mg or 125 mg) or as dispersable tablets for oral suspension (32 mg).