Brahmastra
The Brahmastra (Sanskrit: ब्रह्मास्त्र, romanized: Brahmāstra, lit. 'Astra of Brahma') is a celestial weapon (astra) created and owned by the god Brahma along with its more powerful variant, the Brahmashirastra. The later is considered as the most destructive, powerful, and irresistible weapon mentioned in all of Hinduism.
Only a handful of gods and warrior-heros, namely Parashurama, Rama, Meghanada, Bhishma, Drona, Karna, Ashwatthama, Arjuna, and Lakshmana, were said to have possessed the knowledge to invoke this weapon.