Brevican

BCAN
Identifiers
Aliases	BCAN, BEHAB, CSPG7, Brevican
External IDs	OMIM: 600347; MGI: 1096385; HomoloGene: 7244; GeneCards: BCAN; OMA:BCAN - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,659,532 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,000,230 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; Amygdala; ; anterior cingulate cortex; ; right frontal lobe; ; nucleus accumbens; ; caudate nucleus; ; putamen; ; ganglionic eminence; ; prefrontal cortex; ; Brodmann area 9;
	Top expressed in
	superior frontal gyrus; ; entorhinal cortex; ; primary visual cortex; ; perirhinal cortex; ; CA3 field; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; central gray substance of midbrain; ; nucleus of stria terminalis; ; superior colliculus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	hyaluronic acid binding; carbohydrate binding; extracellular matrix structural constituent;
Cellular component	membrane; extracellular region; lysosomal lumen; Golgi lumen; anchored component of membrane; extracellular matrix; glutamatergic synapse;
Biological process	skeletal system development; chondroitin sulfate biosynthetic process; extracellular matrix organization; central nervous system development; chondroitin sulfate catabolic process; dermatan sulfate biosynthetic process; hippocampus development; cell adhesion; synapse maturation;
	Sources:Amigo / QuickGO
Orthologs
	63827
	12032
	ENSG00000132692
	ENSMUSG00000004892
	Q96GW7
	Q61361
	NM_021948; NM_198427
	NM_001109758; NM_007529
	NP_068767; NP_940819
	NP_001103228; NP_031555
	Wikidata
View/Edit Human	View/Edit Mouse

Brevican core protein is a protein that in humans is encoded by the BCAN gene. Brevican is a member of the lectican protein family.

Brevican is localised to the surface of neurons in the brain. In melanocytic cells, BCAN gene expression may be regulated by MITF.

Brevican is involved in maintaining molecule networks around neurons and may possibly be associated with slower brain ageing and Alzheimer's prevention.