Epidermolytic hyperkeratosis

Epidermolytic ichthyosis (EI), is a severe form of dry scaly skin, that initially presents with redness, blisters, erosions, and peeling in a newborn baby. Hyperkeratosis typically develops several months later. Other symptoms include itch, painful fissures, strong body odor, and absence of sweat. Symptoms vary in severity and extent of skin involvement. The two main types are divided into one involving palms and soles and the other without.

EI is caused by a genetic mutation. The condition involves the clumping of keratin filaments.

The condition is rare, affecting around 1 in 200,000 to 300,000 babies.