Butriptyline

Butriptyline
Clinical data
Trade names	Evadyne, others
Other names	AY-62014
Routes of; administration	Oral
ATC code	N06AA15 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances); In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	?
Protein binding	>90%
Metabolism	Hepatic (N-demethylation)
Metabolites	Norbutriptyline
Elimination half-life	20 hours
Identifiers
	IUPAC name (±)-3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-yl)-N,N,2-trimethylpropan-1-amine;
CAS Number	35941-65-2 ; HCl: 5585-73-9 ;
PubChem CID	21772;
DrugBank	DB09016 ;
ChemSpider	20462 ;
UNII	Z22441975X; HCl: LIJ2H8658W ;
KEGG	D07601 ;
ChEBI	CHEBI:135227 ;
ChEMBL	ChEMBL2110816 ;
CompTox Dashboard (EPA)	DTXSID6022715 ;
Chemical and physical data
Formula	C21H27N
Molar mass	293.454 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES c1cc3c(cc1)CCc2c(cccc2)C3CC(C)CN(C)C;
	InChI InChI=1S/C21H27N/c1-16(15-22(2)3)14-21-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)21/h4-11,16,21H,12-15H2,1-3H3 ; Key:ALELTFCQZDXAMQ-UHFFFAOYSA-N ;
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Butriptyline, sold under the brand name Evadyne among others, is a tricyclic antidepressant (TCA) that has been used in the United Kingdom and several other European countries for the treatment of depression but appears to no longer be marketed. Along with trimipramine, iprindole, and amoxapine, it has been described as an "atypical" or "second-generation" TCA due to its relatively late introduction and atypical pharmacology. It was very little-used compared to other TCAs, with the number of prescriptions dispensed only in the thousands.