Complement component 2

C2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesC2, ARMD14, CO2, complement component 2, complement C2
External IDsOMIM: 613927; MGI: 88226; HomoloGene: 45; GeneCards: C2; OMA:C2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

717

12263

Ensembl

ENSMUSG00000024371

UniProt

P06681
Q5JP69

P21180

RefSeq (mRNA)

NM_013484

RefSeq (protein)

NP_038512

Location (UCSC)Chr 6: 31.9 – 31.95 MbChr 17: 35.08 – 35.12 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Complement C2 is a protein that in humans is encoded by the C2 gene. The protein encoded by this gene is part of the classical pathway of the complement system, acting as a multi-domain serine protease. Deficiency of C2 has been associated with certain autoimmune diseases.

The Complement system is generated to regulate self protection from infection. The overall Complement system is composed of protein groups that collaborate in destroying foreign invaders, which ultimately remove debris from cells and tissues. When the body detects a foreign invader, the body signals the Complement system and the Complement component 2 protein attaches to Complement system 4 resulting in an immune response. Complement component 2 protein is critical for regulating the body's immune response.