C3a receptor

C3AR1
Identifiers
Aliases	C3AR1, AZ3B, C3AR, HNFAG09, complement component 3a receptor 1, complement C3a receptor 1
External IDs	OMIM: 605246; MGI: 1097680; HomoloGene: 2992; GeneCards: C3AR1; OMA:C3AR1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	8,066,359 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	122,833,120 bp
RNA expression pattern
	Top expressed in
	monocyte; ; trabecular bone; ; decidua; ; amniotic fluid; ; bone marrow; ; blood; ; appendix; ; lower lobe of lung; ; bone marrow cells; ; superficial temporal artery;
	Top expressed in
	stroma of bone marrow; ; calvaria; ; ankle joint; ; ankle; ; lumbar subsegment of spinal cord; ; internal carotid artery; ; external carotid artery; ; sciatic nerve; ; white adipose tissue; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; complement receptor activity; complement component C3a receptor activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; azurophil granule membrane; specific granule membrane;
Biological process	blood circulation; signal transduction; chemotaxis; positive regulation of neutrophil chemotaxis; positive regulation of angiogenesis; positive regulation of macrophage chemotaxis; inflammatory response; positive regulation of vascular endothelial growth factor production; G protein-coupled receptor signaling pathway; regulation of complement activation; phospholipase C-activating G protein-coupled receptor signaling pathway; neutrophil degranulation; leukocyte migration; cell chemotaxis; complement receptor mediated signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	719
	12267
	ENSG00000171860
	ENSMUSG00000040552
	Q16581
	O09047
	NM_004054; NM_001326475; NM_001326477
	NM_009779
	NP_001313404; NP_001313406; NP_004045
	NP_033909
	Wikidata
View/Edit Human	View/Edit Mouse

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.

The receptor binds to complement component C3a, although there is limited evidence that this receptor also binds C4a in lesser mammals. This has yet to be proven true in humans. C3a receptor modulates immunity, arthritis, diet-induced obesity and cancers.