C5AR2

C5AR2
Identifiers
Aliases	C5AR2, C5L2, GPR77, complement component 5a receptor 2, complement C5a receptor 2, C5a2
External IDs	OMIM: 609949; MGI: 2442013; HomoloGene: 49549; GeneCards: C5AR2; OMA:C5AR2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,347,329 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	15,978,079 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; spleen; ; right lung; ; testicle; ; upper lobe of left lung; ; gastric mucosa; ; bone marrow cells; ; left uterine tube;
	Top expressed in
	granulocyte; ; yolk sac; ; placenta; ; secondary oocyte; ; liver; ; bone marrow; ; primary oocyte; ; jejunum; ; esophagus; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signal transducer activity; complement component C5a receptor activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; plasma membrane; basal plasma membrane; apical part of cell; membrane; integral component of plasma membrane;
Biological process	negative regulation of neutrophil chemotaxis; chemotaxis; G protein-coupled receptor signaling pathway; negative regulation of tumor necrosis factor production; signal transduction; positive regulation of ERK1 and ERK2 cascade; positive regulation of epithelial cell proliferation; regulation of complement activation; inflammatory response; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; complement component C5a signaling pathway; complement receptor mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	27202
	319430
	ENSG00000134830
	ENSMUSG00000074361
	Q9P296
	Q8BW93
	NM_001271749; NM_001271750; NM_018485
	NM_001146005; NM_176912
	NP_001258678; NP_001258679; NP_060955
	NP_001139477; NP_795886
	Wikidata
View/Edit Human	View/Edit Mouse

Complement component 5a receptor 2 is a protein of the complement system that in humans is encoded by the C5AR2 gene. It is highly expressed in the blood and spleen, predominantly by myeloid cells.