C6orf118 (Chromosome 6, Open Reading Frame 118) is a protein in humans (Homo sapiens), which is encoded by the C6orf118 gene. The protein domain, translin-associated factor X-interacting N-terminus (TRAX), is involved in RNA binding and RNA nuclease activity and in the regulation of mitochondrial function and cellular homeostasis. TRAX interacts with translin, a DNA-binding protein that binds to consensus sequences at breakpoint junctions of chromosomal translocation. TRAX in general contains bipartite nuclear targeting sequences, which may provide nuclear transport for translin, as translin lacks any nuclear targeting motifs. This protein is localized to the mitochondria.
Earlier experiments involving mutant cells showed deletion of translin in mice (Mus musculus) leads to a complete loss of TRAX protein without affecting TRAX mRNA levels, indicating the stability of TRAX protein is dependent on the interaction with translin.
