Carbonic anhydrase II

CA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCA2, CA-II, CAC, CAII, Car2, HEL-76, HEL-S-282, Carbonic anhydrase II, carbonic anhydrase 2
External IDsOMIM: 611492; MGI: 88269; HomoloGene: 37256; GeneCards: CA2; OMA:CA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

760

12349

Ensembl

ENSG00000104267

ENSMUSG00000027562

UniProt

P00918

P00920

RefSeq (mRNA)

NM_001293675
NM_000067

NM_009801
NM_001357334

RefSeq (protein)

NP_000058
NP_001280604

NP_033931
NP_001344263

Location (UCSC)Chr 8: 85.46 – 85.48 MbChr 3: 14.95 – 14.97 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Carbonic anhydrase II (gene name CA2) is one of sixteen forms of human α carbonic anhydrases. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of bicarbonate ions in the proximal tubule. Loss of carbonic anhydrase activity in bones impairs the ability of osteoclasts to promote bone resorption, leading to osteopetrosis.