CABLES1

CABLES1
Identifiers
Aliases	CABLES1, CABL1, CABLES, HsT2563, IK3-1, Cdk5 and Abl enzyme substrate 1
External IDs	OMIM: 609194; MGI: 1927065; HomoloGene: 11097; GeneCards: CABLES1; OMA:CABLES1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	23,260,470 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	12,078,687 bp
RNA expression pattern
	Top expressed in
	putamen; ; nucleus accumbens; ; caudate nucleus; ; internal globus pallidus; ; external globus pallidus; ; Amygdala; ; pars reticulata; ; right frontal lobe; ; entorhinal cortex; ; cingulate gyrus;
	Top expressed in
	habenula; ; cumulus cell; ; lumbar subsegment of spinal cord; ; nucleus of stria terminalis; ; lacrimal gland; ; otic vesicle; ; substantia nigra; ; central gray substance of midbrain; ; Paneth cell; ; suprachiasmatic nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	cell cycle; regulation of cell cycle; cell division; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	91768
	63955
	ENSG00000134508
	ENSMUSG00000040957
	Q8TDN4
	Q9ESJ1
	NM_001100619; NM_001256438; NM_138375
	NM_001146287; NM_022021
	NP_001094089; NP_001243367; NP_612384
	NP_001139759; NP_071304
	Wikidata
View/Edit Human	View/Edit Mouse

CDK5 and ABL1 enzyme substrate 1 is a protein that in humans is encoded by the CABLES1 gene.

CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that plays a role in proliferation and/or cell differentiation. [supplied by OMIM]. It is a tumor suppressor gene which losing it (by mutations, knockout, knockdown or inactivation) may lead to colorectal cancer CRC.