CABYR

CABYR
Identifiers
Aliases	CABYR, CABYRa, CABYRc, CABYRc/d, CABYRe, CBP86, CT88, FSP-2, FSP2, calcium binding tyrosine phosphorylation regulated
External IDs	OMIM: 612135; MGI: 1918382; HomoloGene: 49299; GeneCards: CABYR; OMA:CABYR - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	24,161,600 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	12,888,317 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; gonad; ; oocyte; ; right uterine tube; ; secondary oocyte; ; anterior pituitary; ; anterior cingulate cortex; ; testicle;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; primary visual cortex; ; ascending aorta; ; superior frontal gyrus; ; aortic valve; ; dentate gyrus of hippocampal formation granule cell; ; embryo; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; enzyme binding; calcium ion binding; protein binding; protein domain specific binding; metal ion binding; protein heterodimerization activity;
Cellular component	cytoplasm; sperm principal piece; cell projection; motile cilium; cilium; sperm fibrous sheath; cytoskeleton; nucleus; sperm end piece; cytosol; extracellular region;
Biological process	sperm capacitation; epithelial cilium movement involved in extracellular fluid movement;
	Sources:Amigo / QuickGO
Orthologs
	26256
	71132
	ENSG00000154040
	ENSMUSG00000024430
	O75952
	Q9D424
NM_001308231; NM_012189; NM_138643; NM_138644; NM_153768;
	NM_153769; NM_153770
	NM_001042418; NM_001042419; NM_001042420; NM_027687; NM_181731
NP_001295160; NP_036321; NP_619584; NP_619585; NP_722452;
	NP_722453; NP_722454; NP_001295160.1
	NP_001035883; NP_001035884; NP_001035885; NP_081963; NP_859420
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium-binding tyrosine phosphorylation-regulated protein is a protein that in humans is encoded by the CABYR gene.

To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Transcript variants of this gene encode multiple protein isoforms. An additional transcript and isoform has not been fully characterized.