Cav2.1

CACNA1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BXK
Identifiers
Aliases	CACNA1A, APCA, BI, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6, Cav2.1, calcium voltage-gated channel subunit alpha1 A, EIEE42, DEE42
External IDs	OMIM: 601011; MGI: 109482; HomoloGene: 56383; GeneCards: CACNA1A; OMA:CACNA1A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	13,633,025 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,366,875 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; Brodmann area 23; ; postcentral gyrus; ; Pons; ; primary visual cortex; ; superior frontal gyrus; ; endothelial cell; ; middle temporal gyrus; ; buccal mucosa cell;
	Top expressed in
	cerebellar cortex; ; superior frontal gyrus; ; lobe of cerebellum; ; cerebellar vermis; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; Rostral migratory stream; ; inferior colliculi; ; primary motor cortex; ; neural layer of retina;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; ion channel activity; voltage-gated ion channel activity; syntaxin binding; protein binding; voltage-gated calcium channel activity; calcium channel activity; high voltage-gated calcium channel activity; amyloid-beta binding;
Cellular component	cytoplasm; voltage-gated calcium channel complex; cell projection; nucleus; membrane; integral component of membrane; plasma membrane; soma;
Biological process	calcium ion transport; cell death; transmembrane transport; membrane depolarization during action potential; regulation of ion transmembrane transport; ion transport; transport; regulation of insulin secretion; calcium ion transmembrane transport; positive regulation of cytosolic calcium ion concentration; membrane depolarization; chemical synaptic transmission; modulation of chemical synaptic transmission; calcium ion import; response to amyloid-beta; cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	773
	12286
	ENSG00000141837
	ENSMUSG00000034656
	O00555
	P97445
	NM_023035; NM_000068; NM_001127221; NM_001127222; NM_001174080
	NM_001252059; NM_001252060; NM_001252061; NM_007578
	NP_000059; NP_001120693; NP_001120694; NP_001167551; NP_075461
	NP_001238988; NP_001238989; NP_001238990; NP_031604
	Wikidata
View/Edit Human	View/Edit Mouse

Ca_v2.1, also called the P/Q voltage-dependent calcium channel, is a calcium channel found mainly in the brain. Specifically, it is found on the presynaptic terminals of neurons in the brain and cerebellum. Ca_v2.1 plays an important role in controlling the release of neurotransmitters between neurons. It is composed of multiple subunits, including alpha-1, beta, alpha-2/delta, and gamma subunits. The alpha-1 subunit is the pore-forming subunit, meaning that the calcium ions flow through it. Different kinds of calcium channels have different isoforms (versions) of the alpha-1 subunit. Ca_v2.1 has the alpha-1A subunit, which is encoded by the CACNA1A gene. Mutations in CACNA1A have been associated with various neurologic disorders, including familial hemiplegic migraine, episodic ataxia type 2, and spinocerebellar ataxia type 6.