Cav1.2

CACNA1C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T0J, 2BE6, 2F3Z, 2LQC, 3G43, 3OXQ
Identifiers
Aliases	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS, calcium voltage-gated channel subunit alpha1 C, TS. LQT8
External IDs	OMIM: 114205; MGI: 103013; HomoloGene: 55484; GeneCards: CACNA1C; OMA:CACNA1C - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	2,697,950 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	119,173,851 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right coronary artery; ; muscle layer of sigmoid colon; ; left ventricle; ; body of uterus; ; right auricle of heart; ; myometrium; ; smooth muscle tissue; ; popliteal artery; ; tibial arteries;
	Top expressed in
	cardiac muscle tissue of left ventricle; ; interventricular septum; ; right ventricle; ; Rostral migratory stream; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; atrium; ; medial geniculate nucleus; ; olfactory tubercle; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel activity; metal ion binding; voltage-gated ion channel activity; ion channel activity; protein binding; alpha-actinin binding; voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in cardiac muscle cell action potential; high voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in AV node cell action potential; calmodulin binding;
Cellular component	cytoplasm; voltage-gated calcium channel complex; integral component of membrane; membrane; postsynaptic density; plasma membrane; Z discdkac; L-type voltage-gated calcium channel complex; integral component of plasma membrane; cell junction; dendrite; sarcolemma; cell projection; perikaryon; synapse; postsynaptic membrane; T-tubule;
Biological process	calcium ion transport into cytosol; regulation of insulin secretion; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; positive regulation of cytosolic calcium ion concentration; cell communication by electrical coupling involved in cardiac conduction; regulation of ion transmembrane transport; ion transport; calcium-mediated signaling using extracellular calcium source; transmembrane transport; calcium ion transport; regulation of ventricular cardiac muscle cell action potential; embryonic forelimb morphogenesis; immune system development; regulation of heart rate by cardiac conduction; membrane depolarization during cardiac muscle cell action potential; calcium ion transmembrane transport via high voltage-gated calcium channel; membrane depolarization during AV node cell action potential; heart development; membrane depolarization during atrial cardiac muscle cell action potential; cardiac muscle cell action potential involved in contraction; calcium ion transmembrane transport; camera-type eye development; cardiac conduction; calcium ion import; positive regulation of adenylate cyclase activity;
	Sources:Amigo / QuickGO
Orthologs
	775
	12288
	ENSG00000151067; ENSG00000285479
	ENSMUSG00000051331
	Q13936
	Q01815
NM_000719; NM_001129827; NM_001129829; NM_001129830; NM_001129831;
	NM_001129832; NM_001129833; NM_001129834; NM_001129835; NM_001129836; NM_001129837; NM_001129838; NM_001129839; NM_001129840; NM_001129841; NM_001129842; NM_001129843; NM_001129844; NM_001129846; NM_001167623; NM_001167624; NM_001167625; NM_199460
NM_001159533; NM_001159534; NM_001159535; NM_001255997; NM_001255998;
	NM_001255999; NM_001256000; NM_001256001; NM_001256002; NM_009781; NM_001290335
NP_000710; NP_001123299; NP_001123301; NP_001123302; NP_001123303;
	NP_001123304; NP_001123305; NP_001123306; NP_001123307; NP_001123308; NP_001123309; NP_001123310; NP_001123311; NP_001123312; NP_001123313; NP_001123314; NP_001123315; NP_001123316; NP_001123318; NP_001161095; NP_001161096; NP_001161097; NP_955630
NP_001153005; NP_001153006; NP_001153007; NP_001242926; NP_001242927;
	NP_001242928; NP_001242929; NP_001242930; NP_001242931; NP_001277264; NP_033911
	Wikidata
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Calcium channel, voltage-dependent, L type, alpha 1C subunit (also known as Ca_v1.2) is a protein that in humans is encoded by the CACNA1C gene. Ca_v1.2 is a subunit of L-type voltage-dependent calcium channel.