CACNG3

CACNG3
Identifiers
Aliases	CACNG3, calcium voltage-gated channel auxiliary subunit gamma 3
External IDs	OMIM: 606403; MGI: 1859165; HomoloGene: 4767; GeneCards: CACNG3; OMA:CACNG3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	24,362,412 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	122,368,616 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; Brodmann area 46; ; orbitofrontal cortex; ; Region I of hippocampus proper; ; dorsolateral prefrontal cortex; ; superior frontal gyrus; ; gonad; ; right frontal lobe; ; postcentral gyrus; ; cingulate gyrus;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; prefrontal cortex; ; dentate gyrus of hippocampal formation granule cell; ; piriform cortex; ; primary motor cortex; ; olfactory tubercle; ; cingulate gyrus; ; neural layer of retina; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	voltage-gated calcium channel activity; voltage-gated ion channel activity; channel regulator activity; calcium channel activity; PDZ domain binding; ionotropic glutamate receptor binding;
Cellular component	voltage-gated calcium channel complex; integral component of membrane; endocytic vesicle membrane; plasma membrane; AMPA glutamate receptor complex; membrane; somatodendritic compartment; dendrite; excitatory synapse; postsynaptic density membrane; Schaffer collateral - CA1 synapse; glutamatergic synapse; integral component of postsynaptic density membrane;
Biological process	transmission of nerve impulse; regulation of ion transmembrane transport; ion transport; calcium ion transmembrane transport; calcium ion transport; regulation of AMPA receptor activity; protein targeting; protein localization; positive regulation of AMPA receptor activity; neurotransmitter receptor localization to postsynaptic specialization membrane; positive regulation of synaptic transmission, glutamatergic; neurotransmitter receptor transport, postsynaptic endosome to lysosome; postsynaptic neurotransmitter receptor diffusion trapping; neurotransmitter receptor internalization; cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	10368
	54376
	ENSG00000006116
	ENSMUSG00000066189
	O60359
	Q9JJV5
	NM_006539
	NM_019430
	NP_006530
	NP_062303
	Wikidata
View/Edit Human	View/Edit Mouse

Voltage-dependent calcium channel gamma-3 subunit is a protein that in humans is encoded by the CACNG3 gene.

L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This protein is similar to the mouse stargazin protein, mutations in which have been associated with absence seizures, also known as petit-mal or spike-wave seizures. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family. This gene is a candidate gene for a familial infantile convulsive disorder with paroxysmal choreoathetosis.