CACTIN

CACTIN
Identifiers
Aliases	CACTIN, C19orf29, NY-REN-24, fSAPc, cactin, spliceosome C complex subunit
External IDs	OMIM: 618536; MGI: 1917562; HomoloGene: 69553; GeneCards: CACTIN; OMA:CACTIN - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,626,815 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,162,076 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; granulocyte; ; right ovary; ; left ovary; ; right hemisphere of cerebellum; ; left uterine tube; ; apex of heart; ; body of uterus; ; gastrocnemius muscle; ; mucosa of transverse colon;
	Top expressed in
	otic vesicle; ; interventricular septum; ; hand; ; abdominal wall; ; primitive streak; ; epiblast; ; gastrula; ; primary oocyte; ; mesenteric lymph nodes; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	catalytic step 2 spliceosome; nucleoplasm; spliceosomal complex; extracellular exosome; nucleus; cytosol; nuclear speck; cytoplasm;
Biological process	negative regulation of protein phosphorylation; mRNA splicing, via spliceosome; immune system process; negative regulation of type I interferon-mediated signaling pathway; cellular response to tumor necrosis factor; mRNA processing; negative regulation of interferon-beta production; negative regulation of lipopolysaccharide-mediated signaling pathway; multicellular organism development; negative regulation of interleukin-8 production; negative regulation of toll-like receptor signaling pathway; cellular response to interleukin-1; RNA splicing; negative regulation of tumor necrosis factor production; innate immune response; cellular response to lipopolysaccharide; negative regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	58509
	70312
	ENSG00000105298
	ENSMUSG00000034889
	Q8WUQ7
	Q9CS00
	NM_001080543; NM_021231
	NM_027381
	NP_001074012; NP_067054
	NP_081657
	Wikidata
View/Edit Human	View/Edit Mouse

Cactin also known as renal carcinoma antigen NY-REN-24 is a protein that in humans is encoded by the CACTIN gene.

Cactin was originally identified in Drosophila (fruit flies). The cactin gene is product is involved in the regulation of the innate immune system. It acts as negative regulator of the toll-like receptor, Interferon regulatory factor (IRF) and the canonical NF-kappa-B signaling pathways.