CALML5

CALML5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B1U
Identifiers
Aliases	CALML5, CLSP, calmodulin like 5
External IDs	OMIM: 605183; MGI: 1931464; HomoloGene: 49485; GeneCards: CALML5; OMA:CALML5 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	5,499,570 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	3,888,673 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; vulva; ; skin of leg; ; human penis; ; skin of thigh; ; skin of hip; ; skin of arm; ; nipple; ; minor salivary glands; ; parotid gland;
	Top expressed in
	lip; ; skin of external ear; ; esophagus; ; umbilical cord; ; skin of abdomen; ; superior surface of tongue; ; skin of back; ; condyle; ; fossa; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; calcium ion binding; enzyme regulator activity;
Cellular component	extracellular region; ficolin-1-rich granule lumen; nucleus;
Biological process	signal transduction; epidermis development; neutrophil degranulation; calcium-mediated signaling; regulation of catalytic activity; spindle pole body organization;
	Sources:Amigo / QuickGO
Orthologs
	51806
	80796
	ENSG00000178372
	ENSMUSG00000033765
	Q9NZT1
	Q9JM83
	NM_017422
	NM_020036
	NP_059118
	NP_064420
	Wikidata
View/Edit Human	View/Edit Mouse

Calmodulin-like protein 5 is a protein that in humans is encoded by the CALML5 gene.

This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.