CAMK1

CAMK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4FG7, 4FG8, 4FG9, 4FGB
Identifiers
Aliases	CAMK1, CAMKI, calcium/calmodulin dependent protein kinase I, CaMKI-alpha, CaM kinase I alpha
External IDs	OMIM: 604998; MGI: 1098535; HomoloGene: 117458; GeneCards: CAMK1; OMA:CAMK1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	9,769,992 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	113,320,945 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal cortex; ; right frontal lobe; ; nucleus accumbens; ; prefrontal cortex; ; caudate nucleus; ; monocyte; ; Amygdala; ; left uterine tube; ; putamen;
	Top expressed in
	superior frontal gyrus; ; stroma of bone marrow; ; primary visual cortex; ; external carotid artery; ; dorsomedial hypothalamic nucleus; ; internal carotid artery; ; right kidney; ; arcuate nucleus; ; myocardium of ventricle; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; catalytic activity; ATP binding; calmodulin-dependent protein kinase activity; calmodulin binding;
Cellular component	cytoplasm; nucleus; intracellular anatomical structure; postsynaptic density; glutamatergic synapse; cytosol;
Biological process	cell differentiation; positive regulation of synapse structural plasticity; positive regulation of muscle cell differentiation; regulation of muscle cell differentiation; phosphorylation; positive regulation of syncytium formation by plasma membrane fusion; regulation of histone H3-K9 acetylation; negative regulation of protein binding; positive regulation of dendritic spine development; nervous system development; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of protein acetylation; regulation of protein localization; positive regulation of protein export from nucleus; multicellular organism development; protein phosphorylation; nucleocytoplasmic transport; positive regulation of neuron projection development; cell cycle; metabolism; regulation of protein binding; positive regulation of transcription by RNA polymerase II; signal transduction; peptidyl-threonine phosphorylation; intracellular signal transduction; regulation of synapse organization;
	Sources:Amigo / QuickGO
Orthologs
	8536
	52163
	ENSG00000134072
	ENSMUSG00000030272
	Q14012
	Q91YS8
	NM_003656
	NM_133926
	NP_003647; NP_003647.1
	NP_598687
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.