CAMK2D

CAMK2D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VN9, 2W2C, 2WEL, 3GP2
Identifiers
Aliases	CAMK2D, CAMKD, calcium/calmodulin dependent protein kinase II delta
External IDs	OMIM: 607708; MGI: 1341265; HomoloGene: 55561; GeneCards: CAMK2D; OMA:CAMK2D - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	113,761,927 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	126,639,975 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; lateral nuclear group of thalamus; ; cardiac muscle tissue of right atrium; ; middle temporal gyrus; ; Brodmann area 23; ; right ventricle; ; entorhinal cortex; ; tibialis anterior muscle; ; deltoid muscle; ; endothelial cell;
	Top expressed in
	anterior amygdaloid area; ; neural layer of retina; ; lobe of cerebellum; ; cerebellar vermis; ; lateral septal nucleus; ; medial geniculate nucleus; ; dorsomedial hypothalamic nucleus; ; atrium; ; lateral hypothalamus; ; ventral tegmental area;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity; ATP binding; protein kinase activity; titin binding; transferase activity; protein homodimerization activity; protein binding; nucleotide binding; sodium channel inhibitor activity; calmodulin-dependent protein kinase activity; protein serine/threonine kinase activity; transmembrane transporter binding; calmodulin binding; identical protein binding;
Cellular component	endocytic vesicle membrane; membrane; sarcoplasmic reticulum membrane; plasma membrane; nucleoplasm; sarcoplasmic reticulum; sarcolemma; neuron projection; nucleus; cytoplasm; cytosol; calcium channel complex;
Biological process	regulation of heart contraction; interferon-gamma-mediated signaling pathway; regulation of transcription by RNA polymerase II; regulation of membrane depolarization; positive regulation of cardiac muscle hypertrophy; protein phosphorylation; cellular response to calcium ion; regulation of cardiac muscle cell action potential involved in regulation of contraction; regulation of histone deacetylase activity; regulation of cellular localization; negative regulation of sodium ion transmembrane transport; phosphorylation; regulation of the force of heart contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of ryanodine-sensitive calcium-release channel activity; negative regulation of sodium ion transmembrane transporter activity; MAPK cascade; protein complex oligomerization; regulation of cell growth; regulation of cellular response to heat; regulation of cell communication by electrical coupling involved in cardiac conduction; regulation of heart rate by cardiac conduction; nervous system development; cell differentiation; regulation of cell communication by electrical coupling; positive regulation of cardiac muscle cell apoptotic process; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; endoplasmic reticulum calcium ion homeostasis; protein autophosphorylation; relaxation of cardiac muscle; cardiac muscle cell contraction; regulation of cardiac muscle cell action potential; regulation of relaxation of cardiac muscle; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;
	Sources:Amigo / QuickGO
Orthologs
	817
	108058
	ENSG00000145349
	ENSMUSG00000053819
	Q13557
	Q6PHZ2
NM_001221; NM_172114; NM_172115; NM_172127; NM_172128;
	NM_172129; NM_001321566; NM_001321567; NM_001321568; NM_001321569; NM_001321570; NM_001321571; NM_001321572; NM_001321573; NM_001321574; NM_001321575; NM_001321576; NM_001321577; NM_001321578; NM_001321579; NM_001321580; NM_001321581; NM_001321582; NM_001321583; NM_001321584; NM_001321585; NM_001321586; NM_001321587; NM_001321588; NM_001321589; NM_001321590; NM_001321591; NM_001321592; NM_001396964; NM_001396965; NM_001396966; NM_001396967; NM_001399855; NM_001399856; NM_001399857; NM_001399858; NM_001399859; NM_001399860; NM_001399861; NM_001399862; NM_001399863; NM_001399864; NM_001399865
NM_001025438; NM_001025439; NM_001293663; NM_001293664; NM_001293665;
	NM_001293666; NM_023813; NM_001346635; NM_001346636
NP_001212; NP_001308495; NP_001308496; NP_001308497; NP_001308498;
	NP_001308499; NP_001308500; NP_001308501; NP_001308502; NP_001308503; NP_001308504; NP_001308505; NP_001308506; NP_001308507; NP_001308508; NP_001308509; NP_001308510; NP_001308511; NP_001308512; NP_001308513; NP_001308514; NP_001308515; NP_001308516; NP_001308517; NP_001308518; NP_001308519; NP_001308520; NP_001308521; NP_742112; NP_742113; NP_742125; NP_742126; NP_742127
NP_001020609; NP_001020610; NP_001280592; NP_001280593; NP_001280594;
	NP_001280595; NP_001333564; NP_001333565; NP_076302
	Wikidata
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Calcium/calmodulin-dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the CAMK2D gene.

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca²⁺/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Four alternatively spliced transcript variants that encode three different isoforms have been characterized to date. Distinct isoforms of this chain have different expression patterns.