CAMKK1

CAMKK1
Identifiers
Aliases	CAMKK1, CAMKKA, calcium/calmodulin-dependent protein kinase kinase 1, calcium/calmodulin dependent protein kinase kinase 1
External IDs	OMIM: 611411; MGI: 1891766; HomoloGene: 10327; GeneCards: CAMKK1; OMA:CAMKK1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,894,891 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	72,932,899 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; pancreatic ductal cell; ; Brodmann area 9; ; prefrontal cortex; ; right hemisphere of cerebellum; ; middle temporal gyrus; ; primary visual cortex; ; endothelial cell; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; hippocampus proper; ; facial motor nucleus; ; anterior horn of spinal cord; ; central gray substance of midbrain; ; lumbar subsegment of spinal cord; ; primary motor cortex; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; calmodulin-dependent protein kinase activity; calmodulin binding;
Cellular component	cytosol; nucleus; cytoplasm; nucleoplasm;
Biological process	protein phosphorylation; phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; intracellular signal transduction; positive regulation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	84254
	55984
	ENSG00000004660
	ENSMUSG00000020785
	Q8N5S9
	Q8VBY2
	NM_032294; NM_172206; NM_172207
	NM_018883; NM_001362841
	NP_115670; NP_757343; NP_757344
	NP_061371; NP_001349770
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene.

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase (CAMK) subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.