CAMP responsive element modulator

CREM
Identifiers
Aliases	CREM, CREM-2, ICER, hCREM-2, cAMP responsive element modulator
External IDs	OMIM: 123812; MGI: 88495; HomoloGene: 84591; GeneCards: CREM; OMA:CREM - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	35,212,958 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	3,337,748 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; right adrenal cortex; ; left adrenal cortex; ; sperm; ; gallbladder; ; anterior pituitary; ; gonad; ; left uterine tube; ; C1 segment;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; adrenal gland; ; lumbar spinal ganglion; ; right kidney; ; proximal tubule; ; islet of Langerhans; ; atrioventricular valve; ; muscle of thigh;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; cAMP response element binding protein binding; DNA-binding transcription factor activity; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; transcription regulator complex; nucleus;
Biological process	cell differentiation; regulation of transcription, DNA-templated; glycosphingolipid metabolic process; rhythmic process; transcription, DNA-templated; fatty acid metabolic process; multicellular organism development; retinoic acid receptor signaling pathway; regulation of circadian rhythm; spermatogenesis; glucose metabolic process; positive regulation of transcription by RNA polymerase II; signal transduction; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1390
	12916
	ENSG00000095794
	ENSMUSG00000063889
	Q03060
	P27699
NM_001267562; NM_001267563; NM_001267564; NM_001267565; NM_001267566;
	NM_001267567; NM_001267568; NM_001267569; NM_001267570; NM_001881; NM_181571; NM_182717; NM_182718; NM_182719; NM_182720; NM_182721; NM_182722; NM_182723; NM_182724; NM_182725; NM_182769; NM_182770; NM_182771; NM_182772; NM_182850; NM_182853; NM_183011; NM_183012; NM_183013; NM_183060; NM_001352445; NM_001352446; NM_001352465; NM_001352466; NM_001352467; NM_001394595; NM_001394598; NM_001394600; NM_001394602; NM_001394603; NM_001394605; NM_001394608; NM_001394610; NM_001394613; NM_001394614; NM_001394615; NM_001394616; NM_001394617; NM_001394618; NM_001394619; NM_001394620; NM_001394621; NM_001394622; NM_001394623; NM_001394625; NM_001394626; NM_001394627; NM_001394628; NM_001394629; NM_001394630; NM_001394631
NM_001110850; NM_001110851; NM_001110852; NM_001110853; NM_001110854;
	NM_001110855; NM_001110856; NM_001110857; NM_001110858; NM_001110859; NM_001271503; NM_001271504; NM_001271505; NM_001271506; NM_013498; NM_001311066; NM_001311067; NM_001374833
NP_001254491; NP_001254492; NP_001254493; NP_001254494; NP_001254495;
	NP_001254496; NP_001254497; NP_001254498; NP_001254499; NP_001872; NP_853549; NP_874386; NP_874387; NP_874388; NP_874389; NP_874390; NP_874392; NP_874393; NP_877570; NP_877571; NP_877572; NP_877573; NP_898829; NP_898830; NP_898831; NP_898883; NP_001339374; NP_001339375; NP_001339394; NP_001339395; NP_001339396
NP_001104320; NP_001104321; NP_001104322; NP_001104323; NP_001104324;
	NP_001104325; NP_001104326; NP_001104327; NP_001104328; NP_001104329; NP_001258432; NP_001258433; NP_001258434; NP_001258435; NP_001297995; NP_001297996; NP_038526; NP_001361762
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP responsive element modulator is a protein that in humans is encoded by the CREM gene, and it belongs to the cAMP-responsive element binding protein family. It has multiple isoforms, which act either as repressors or activators. CREB family is important for in regulating transcription in response to various stresses, metabolic and developmental signals. CREM transcription factors also play an important role in many physiological systems, such as cardiac function, circadian rhythms, locomotion and spermatogenesis.