Calnexin

CANX
Identifiers
Aliases	CANX, CNX, IP90, P90, calnexin
External IDs	OMIM: 114217; MGI: 88261; HomoloGene: 1324; GeneCards: CANX; OMA:CANX - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	179,730,925 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	50,216,500 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; islet of Langerhans; ; Achilles tendon; ; epithelium of colon; ; bone marrow cells; ; ventricular zone; ; tonsil; ; corpus callosum; ; smooth muscle tissue; ; sural nerve;
	Top expressed in
	medullary collecting duct; ; tail of embryo; ; neural layer of retina; ; paraventricular nucleus of hypothalamus; ; primitive streak; ; Epithelium of choroid plexus; ; renal corpuscle; ; genital tubercle; ; gastrula; ; lacrimal gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; apolipoprotein binding; unfolded protein binding; metal ion binding; ionotropic glutamate receptor binding; carbohydrate binding; RNA binding; protein binding;
Cellular component	cytoplasm; integral component of membrane; mitochondria associated membranes; rough endoplasmic reticulum; ribosome; endoplasmic reticulum lumen; endoplasmic reticulum membrane; membrane; melanosome; myelin sheath; dendritic spine; smooth endoplasmic reticulum; axon; soma; endoplasmic reticulum; dendrite cytoplasm; integral component of lumenal side of endoplasmic reticulum membrane; extracellular exosome; extracellular matrix; protein-containing complex; endoplasmic reticulum quality control compartment; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic active zone membrane;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; ageing; protein folding in endoplasmic reticulum; protein secretion; clathrin-dependent endocytosis; synaptic vesicle endocytosis; protein folding; chaperone-mediated protein folding; interleukin-12-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	821
	12330
	ENSG00000283777; ENSG00000127022
	ENSMUSG00000020368
	P27824
	P35564
	NM_001024649; NM_001746
	NM_001110499; NM_001110500; NM_007597
NP_001019820; NP_001737; NP_001350922; NP_001350923; NP_001350924;
	NP_001350925; NP_001350926; NP_001350927; NP_001350928; NP_001350929; NP_001350930
	NP_001103969; NP_001103970; NP_031623
	Wikidata
View/Edit Human	View/Edit Mouse

Calnexin (CNX) is a 67kDa integral protein (that appears variously as a 90kDa, 80kDa, or 75kDa band on western blotting depending on the source of the antibody) of the endoplasmic reticulum (ER). It consists of a large (50 kDa) N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail. In humans, calnexin is encoded by the gene CANX.