Calpain-1 catalytic subunit

CAPN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZCM, 2ARY
Identifiers
Aliases	CAPN1, CANP, CANP1, CANPL1, muCANP, muCL, SPG76, calpain 1
External IDs	OMIM: 114220; MGI: 88263; HomoloGene: 3800; GeneCards: CAPN1; OMA:CAPN1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,212,006 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,065,927 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; skin of leg; ; skin of abdomen; ; minor salivary glands; ; right uterine tube; ; right lobe of thyroid gland; ; olfactory zone of nasal mucosa; ; left lobe of thyroid gland; ; gallbladder; ; ectocervix;
	Top expressed in
	granulocyte; ; lip; ; transitional epithelium of urinary bladder; ; esophagus; ; muscle of thigh; ; corneal stroma; ; lumbar spinal ganglion; ; ankle; ; triceps brachii muscle; ; knee joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; metal ion binding; peptidase activity; protein binding; hydrolase activity; endopeptidase activity; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity;
Cellular component	membrane; focal adhesion; intracellular anatomical structure; mitochondrion; lysosome; extracellular exosome; cytosol; extracellular region; cytoplasm; plasma membrane; ficolin-1-rich granule lumen;
Biological process	extracellular matrix disassembly; receptor catabolic process; positive regulation of cell population proliferation; regulation of macroautophagy; mammary gland involution; neutrophil degranulation; regulation of catalytic activity; cornification; self proteolysis; proteolysis; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	823
	12333
	ENSG00000014216
	ENSMUSG00000024942
	P07384
	O35350
	NM_001198868; NM_001198869; NM_005186
	NM_001110504; NM_007600
	NP_001185797; NP_001185798; NP_005177
	NP_001103974; NP_031626
	Wikidata
View/Edit Human	View/Edit Mouse

Calpain-1 catalytic subunit (CANP 1) is a protein that in humans is encoded by the CAPN1 gene.