Calpain-2 catalytic subunit

CAPN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KFU, 1KFX, 2NQA
Identifiers
Aliases	CAPN2, CANP2, CANPL2, CANPml, mCANP, calpain 2
External IDs	OMIM: 114230; MGI: 88264; HomoloGene: 1326; GeneCards: CAPN2; OMA:CAPN2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	223,776,018 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	182,345,173 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; nasal epithelium; ; glomerulus; ; mucosa of sigmoid colon; ; right uterine tube; ; parotid gland; ; metanephric glomerulus; ; parietal pleura; ; cartilage tissue; ; visceral pleura;
	Top expressed in
	endothelial cell of lymphatic vessel; ; genital tubercle; ; facial motor nucleus; ; gastrula; ; umbilical cord; ; left lung; ; tail of embryo; ; right lung; ; right lung lobe; ; cornea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; cysteine-type peptidase activity; metal ion binding; cytoskeletal protein binding; peptidase activity; protein binding; protein heterodimerization activity; hydrolase activity; calcium-dependent cysteine-type endopeptidase activity; enzyme binding;
Cellular component	Golgi apparatus; pseudopodium; membrane; focal adhesion; perinuclear endoplasmic reticulum; intracellular anatomical structure; dendrite; endoplasmic reticulum; cortical actin cytoskeleton; membrane raft; chromatin; lysosome; extracellular exosome; nucleus; cytosol; cytoplasm; plasma membrane; mitochondrial intermembrane space; external side of plasma membrane; cell projection; soma;
Biological process	response to hypoxia; protein autoprocessing; proteolysis; cellular response to amino acid stimulus; myoblast fusion; proteolysis involved in cellular protein catabolic process; regulation of cytoskeleton organization; blastocyst development; extracellular matrix disassembly; female pregnancy; positive regulation of cardiac muscle cell apoptotic process; regulation of interleukin-6 production; cellular response to interferon-beta; response to hydrogen peroxide; behavioral response to pain; cellular response to lipopolysaccharide; positive regulation of neuron death; positive regulation of myoblast fusion; positive regulation of phosphatidylcholine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	824
	12334
	ENSG00000162909
	ENSMUSG00000026509
	P17655
	O08529
	NM_001146068; NM_001748
	NM_009794
	NP_001139540; NP_001739
	NP_033924
	Wikidata
View/Edit Human	View/Edit Mouse

Calpain-2 catalytic subunit is a protein that in humans is encoded by the CAPN2 gene.