CAPN5

CAPN5
Identifiers
Aliases	CAPN5, ADNIV, HTRA3, VRNI, nCL-3, calpain 5
External IDs	OMIM: 602537; MGI: 1100859; HomoloGene: 31212; GeneCards: CAPN5; OMA:CAPN5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	77,126,155 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	98,178,274 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; gallbladder; ; right lobe of liver; ; stromal cell of endometrium; ; mucosa of esophagus; ; duodenum; ; body of stomach; ; mucosa of ileum; ; palpebral conjunctiva;
	Top expressed in
	transitional epithelium of urinary bladder; ; lumbar spinal ganglion; ; pyloric antrum; ; epithelium of stomach; ; conjunctival fornix; ; mucous cell of stomach; ; perirhinal cortex; ; fetal liver hematopoietic progenitor cell; ; corneal stroma; ; entorhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; cysteine-type peptidase activity; hydrolase activity; calcium-dependent cysteine-type endopeptidase activity;
Cellular component	cell surface; extracellular exosome; intracellular anatomical structure; focal adhesion; cytoplasm;
Biological process	signal transduction; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	726
	12337
	ENSG00000149260
	ENSMUSG00000035547
	O15484
	O08688
	NM_004055
	NM_001301250; NM_007602
	NP_004046
	NP_001288179; NP_031628
	Wikidata
View/Edit Human	View/Edit Mouse

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene.

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.