CAPZB

CAPZB
Identifiers
Aliases	CAPZB, CAPB, CAPPB, CAPZ, capping actin protein of muscle Z-line beta subunit, capping actin protein of muscle Z-line subunit beta
External IDs	OMIM: 601572; MGI: 104652; HomoloGene: 3620; GeneCards: CAPZB; OMA:CAPZB - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	19,485,539 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	139,019,129 bp
RNA expression pattern
	Top expressed in
	muscle layer of sigmoid colon; ; smooth muscle tissue; ; monocyte; ; granulocyte; ; left testis; ; right testis; ; stromal cell of endometrium; ; pylorus; ; popliteal artery; ; tibial arteries;
	Top expressed in
	gastrula; ; granulocyte; ; triceps brachii muscle; ; ascending aorta; ; tibiofemoral joint; ; ankle; ; pyloric antrum; ; yolk sac; ; tail of embryo; ; vastus lateralis muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	actin filament binding; cadherin binding; actin binding; protein binding;
Cellular component	cytoplasm; cytosol; sarcomere; WASH complex; extracellular exosome; cytoskeleton; actin filament; actin cytoskeleton; F-actin capping protein complex;
Biological process	regulation of lamellipodium assembly; barbed-end actin filament capping; regulation of cell morphogenesis; blood coagulation; cytoskeleton organization; actin cytoskeleton organization; actin filament capping; negative regulation of filopodium assembly; endoplasmic reticulum to Golgi vesicle-mediated transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	832
	12345
	ENSG00000077549
	ENSMUSG00000028745
	P47756
	P47757
	NM_001313932; NM_001206540; NM_001206541; NM_001282162; NM_004930
	NM_001037761; NM_001271405; NM_001271406; NM_009798
	NP_001193469; NP_001193470; NP_001269091; NP_001300861; NP_004921
	NP_001032850; NP_001258334; NP_033928
	Wikidata
View/Edit Human	View/Edit Mouse

F-actin-capping protein subunit beta, also known as CapZβ, is a protein that in humans is encoded by the CAPZB gene. CapZβ functions to cap actin filaments at barbed ends in muscle and other tissues.