CARD9

CARD9
Identifiers
Aliases	CARD9, CANDF2, hcaspase recruitment domain family member 9
External IDs	OMIM: 607212; MGI: 2685628; HomoloGene: 14150; GeneCards: CARD9; OMA:CARD9 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	136,373,681 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	26,250,930 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; testicle; ; blood; ; spleen; ; C1 segment; ; bone marrow; ; stromal cell of endometrium; ; bone marrow cells; ; upper lobe of left lung;
	Top expressed in
	granulocyte; ; bone marrow; ; ileum; ; olfactory bulb; ; thymus; ; lung; ; Cerebellum; ; jejunum; ; spleen; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; protein domain specific binding; protein binding; CARD domain binding;
Cellular component	cytoplasm; cytosol; plasma membrane; protein-containing complex;
Biological process	regulation of apoptotic process; response to exogenous dsRNA; immune system process; response to muramyl dipeptide; stimulatory C-type lectin receptor signaling pathway; positive regulation of JNK cascade; response to fungus; defense response to virus; response to peptidoglycan; positive regulation of interleukin-6 production; positive regulation of innate immune response; positive regulation of tumor necrosis factor production; positive regulation of I-kappaB kinase/NF-kappaB signaling; I-kappaB kinase/NF-kappaB signaling; positive regulation of stress-activated MAPK cascade; defense response to Gram-positive bacterium; innate immune response; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	64170
	332579
	ENSG00000187796
	ENSMUSG00000026928
	Q9H257
	A2AIV8
	NM_052814; NM_052813; NM_022352
	NM_001037747
	NP_434700; NP_434701
	NP_001032836
	Wikidata
View/Edit Human	View/Edit Mouse

Caspase recruitment domain-containing protein 9 is an adaptor protein of the CARD-CC protein family, which in humans is encoded by the CARD9 gene. It mediates signals from pattern recognition receptors to activate pro-inflammatory and anti-inflammatory cytokines, regulating inflammation. Homozygous mutations in CARD9 are associated with defective innate immunity against yeasts, like Candida and dermatophytes.