Caspase 2

CASP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PYO, 2P2C, 3R5J, 3R6G, 3R6L, 3R7B, 3R7N, 3R7S, 3RJM
Identifiers
Aliases	CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57, caspase 2
External IDs	OMIM: 600639; MGI: 97295; HomoloGene: 7254; GeneCards: CASP2; OMA:CASP2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	143,307,696 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	42,259,442 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; tendon of biceps brachii; ; trabecular bone; ; skin of hip; ; skin of thigh; ; tonsil; ; ganglionic eminence; ; blood; ; mucosa of sigmoid colon; ; testicle;
	Top expressed in
	saccule; ; otic placode; ; otic vesicle; ; endocardial cushion; ; fetal liver hematopoietic progenitor cell; ; maxillary prominence; ; mandibular prominence; ; thymus; ; hair follicle; ; Gonadal ridge;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; protein domain specific binding; peptidase activity; protein binding; enzyme binding; hydrolase activity; identical protein binding; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in execution phase of apoptosis;
Cellular component	cytoplasm; cytosol; membrane; mitochondrion; nucleus;
Biological process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; execution phase of apoptosis; protein processing; ageing; positive regulation of apoptotic signaling pathway; luteolysis; cellular response to mechanical stimulus; positive regulation of neuron apoptotic process; brain development; intrinsic apoptotic signaling pathway in response to DNA damage; extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of apoptotic process; ectopic germ cell programmed cell death; apoptotic signaling pathway; neural retina development; apoptotic process; regulation of apoptotic process; proteolysis; negative regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	835
	12366
	ENSG00000106144
	ENSMUSG00000029863
	P42575
	P29594
	NM_032983; NM_001224; NM_032982; NM_032984
	NM_007610
	NP_001215; NP_116764; NP_116765
	NP_031636
	Wikidata
View/Edit Human	View/Edit Mouse

Caspase 2 also known as CASP2 is an enzyme that, in humans, is encoded by the CASP2 gene. CASP2 orthologs have been identified in nearly all mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts.