CBLC

CBLC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OP0, 3VRN, 3VRO, 3VRP, 3VRQ, 3VRR
Identifiers
Aliases	CBLC, CBL-3, CBL-SL, RNF57, Cbl proto-oncogene C
External IDs	OMIM: 608453; MGI: 1931457; HomoloGene: 8108; GeneCards: CBLC; OMA:CBLC - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	44,800,652 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,530,734 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; skin of abdomen; ; skin of leg; ; duodenum; ; right lobe of liver; ; body of pancreas; ; jejunal mucosa; ; rectum; ; olfactory zone of nasal mucosa; ; minor salivary glands;
	Top expressed in
	duodenum; ; intestinal villus; ; right kidney; ; epithelium of stomach; ; jejunum; ; lip; ; proximal tubule; ; colon; ; esophagus; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; phosphotyrosine residue binding; calcium ion binding; epidermal growth factor receptor binding; ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; transferase activity; receptor tyrosine kinase binding; zinc ion binding; protein binding;
Cellular component	plasma membrane; membrane raft;
Biological process	negative regulation of epidermal growth factor-activated receptor activity; cell surface receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; protein ubiquitination; regulation of signaling; ubiquitin-dependent protein catabolic process; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23624
	80794
	ENSG00000142273
	ENSMUSG00000040525
	Q9ULV8
	Q80XL1
	NM_001130852; NM_012116
	NM_001161844; NM_023224
	NP_001124324; NP_036248
	NP_001155316; NP_075713
	Wikidata
View/Edit Human	View/Edit Mouse

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM]