CBR1

CBR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WMA, 2PFG, 3BHI, 3BHJ, 3BHM, 4Z3D
Identifiers
Aliases	CBR1, CBR, SDR21C1, hcarbonyl reductase 1, PG-9-KR
External IDs	OMIM: 114830; MGI: 88284; HomoloGene: 37524; GeneCards: CBR1; OMA:CBR1 - orthologs
EC number	1.1.1.197
Gene location (Human)
Chr.	Chromosome 21 (human)
End	36,073,166 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	93,407,393 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; C1 segment; ; corpus callosum; ; olfactory zone of nasal mucosa; ; right adrenal gland; ; right adrenal cortex; ; caudate nucleus; ; mucosa of esophagus; ; putamen;
	Top expressed in
	epithelium of stomach; ; superior surface of tongue; ; duodenum; ; gallbladder; ; pyloric antrum; ; mucous cell of stomach; ; large intestine; ; colon; ; left colon; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity; prostaglandin-E2 9-reductase activity;
Cellular component	cytoplasm; extracellular vesicle; cytosol; extracellular exosome;
Biological process	epithelial cell differentiation; vitamin K metabolic process; cyclooxygenase pathway;
	Sources:Amigo / QuickGO
Orthologs
	873
	12408
	ENSG00000159228
	ENSMUSG00000051483
	P16152
	P48758
	NM_001757; NM_001286789
	NM_007620
	NP_001273718; NP_001748
	NP_031646
	Wikidata
View/Edit Human	View/Edit Mouse

Carbonyl reductase 1, also known as CBR1, is an enzyme which in humans is encoded by the CBR1 gene. The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene.