CCL17

CCL17
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1NR2, 1NR4
Identifiers
Aliases	CCL17, A-152E5.3, ABCD-2, SCYA17, TARC, C-C motif chemokine ligand 17
External IDs	OMIM: 601520; MGI: 1329039; HomoloGene: 2246; GeneCards: CCL17; OMA:CCL17 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	57,416,063 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	95,538,664 bp
RNA expression pattern
	Top expressed in
	testicle; ; appendix; ; lymph node; ; olfactory zone of nasal mucosa; ; upper lobe of left lung; ; gallbladder; ; minor salivary glands; ; rectum; ; bronchial epithelial cell; ; skin of abdomen;
	Top expressed in
	embryo; ; morula; ; Gonadal ridge; ; facial motor nucleus; ; lip; ; blastocyst; ; superior frontal gyrus; ; thymus; ; Sertoli cell; ; visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; CCR chemokine receptor binding; signaling receptor binding; chemokine activity; CCR4 chemokine receptor binding; protein binding;
Cellular component	extracellular region; extracellular space;
Biological process	G protein-coupled receptor signaling pathway; negative regulation of myoblast differentiation; monocyte chemotaxis; chemokine-mediated signaling pathway; cellular response to tumor necrosis factor; cell-cell signaling; neutrophil chemotaxis; multicellular organism development; chemotaxis; positive regulation of GTPase activity; cellular response to interleukin-1; immune response; positive regulation of ERK1 and ERK2 cascade; cellular response to interferon-gamma; lymphocyte chemotaxis; inflammatory response; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	6361
	20295
	ENSG00000102970
	ENSMUSG00000031780
	Q92583
	n/a
	NM_002987
	NM_011332
	NP_002978
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

CCL17 is a powerful chemokine produced in the thymus and by antigen-presenting cells like dendritic cells, macrophages, and monocytes. CCL17 plays a complex role in cancer. It attracts T-regulatory cells allowing for some cancers to evade an immune response. However, in other cancers, such as melanoma, an increase in CCL17 is linked to an improved outcome. CCL17 has also been linked to autoimmune and allergic diseases.