CCL3

CCL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B50, 1B53, 2X69, 2X6G, 3FPU, 3H44, 3KBX, 4RA8, 4ZKB, 5D65, 5COR
Identifiers
Aliases	CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3, C-C motif chemokine ligand 3
External IDs	OMIM: 182283; MGI: 98260; HomoloGene: 88430; GeneCards: CCL3; OMA:CCL3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	36,090,169 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	83,540,181 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; granulocyte; ; spleen; ; monocyte; ; bone marrow cells; ; gallbladder; ; placenta; ; testicle; ; lymph node; ; appendix;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; calvaria; ; spermatid; ; blood; ; dermis; ; secondary oocyte; ; thymus; ; islet of Langerhans; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; cytokine activity; CCR5 chemokine receptor binding; chemokine activity; CCR1 chemokine receptor binding; kinase activity; phospholipase activator activity; calcium-dependent protein kinase C activity; protein binding; identical protein binding; chemoattractant activity; CCR chemokine receptor binding;
Cellular component	cytoplasm; cytosol; intracellular anatomical structure; extracellular region; extracellular space;
Biological process	G protein-coupled receptor signaling pathway; signaling; negative regulation of bone mineralization; positive regulation of protein kinase B signaling; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to cholesterol; positive regulation of calcium-mediated signaling; regulation of sensory perception of pain; protein kinase B signaling; monocyte chemotaxis; negative regulation of osteoclast differentiation; astrocyte cell migration; positive regulation of cell migration; positive regulation of natural killer cell chemotaxis; chemokine-mediated signaling pathway; T cell chemotaxis; cell-cell signaling; cellular response to tumor necrosis factor; eosinophil chemotaxis; cellular response to organic cyclic compound; cellular calcium ion homeostasis; negative regulation of gene expression; neutrophil chemotaxis; cell activation; MAPK cascade; chemotaxis; positive regulation of GTPase activity; positive regulation of neuron apoptotic process; positive regulation of calcium ion import; macrophage chemotaxis; positive regulation of gene expression; cytoskeleton organization; osteoblast differentiation; cellular response to interleukin-1; immune response; positive regulation of ERK1 and ERK2 cascade; regulation of cell shape; positive regulation of tumor necrosis factor production; cellular response to interferon-gamma; lymphocyte chemotaxis; inflammatory response; granulocyte chemotaxis; response to toxic substance; eosinophil degranulation; lipopolysaccharide-mediated signaling pathway; calcium ion transport; calcium-mediated signaling; exocytosis; positive regulation of calcium ion transport; positive chemotaxis; positive regulation of inflammatory response; regulation of signaling receptor activity; cytokine-mediated signaling pathway; regulation of behavior; positive regulation of microglial cell activation; positive regulation of microglial cell migration;
	Sources:Amigo / QuickGO
Orthologs
	6348
	20302
	ENSG00000278567; ENSG00000277632; ENSG00000274221
	ENSMUSG00000000982
	P10147
	P10855
	NM_002983
	NM_011337
	NP_002974
	NP_035467
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.